NephPath 101 – Understanding the tubulointerstitium. – by NSMC2019 intern and nephro-pathologist Vighnesh Walavalkar.
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The tubulointerstitium of the kidney is broadly divided into the cortex and the medulla. These are extremely important components of the kidney, which can show a broad spectrum of changes ranging from subtle to significant, in both acute and chronic kidney injury. Therefore, in order to recognize the pathologic changes in these areas, one must first be familiar with its normal architecture
In this post, we will cover the main histologic features of the normal tubulointerstitium as seen on diagnostic kidney biopsies. For a more in-depth review please refer to my favorite references for kidney pathology: Heptinstall’s Pathology of the Kidney, Silva’s Diagnostic Renal Pathology and Renal Pathophysiology, The Essentials.
Fibrillary glomerulonephritis (GN) is a rare disease which accounts for about 1% of all kidney biopsies. The very first description of the disease was published by Rosenmann and Eliakim in 1977. They described a patient with nephrotic syndrome due to deposition of what they describe as “an amyloid-like material in the glomeruli,” but upon ultrastructural analysis, this material “appeared shorter than amyloid fibrils”
Post by NSMC2019 Intern and Nephrology Fellow – Lovy Gaur
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